By Sayed S. Daoud

This booklet covers present subject matters concerning using proteomic techniques in melanoma treatment in addition to expected demanding situations which can come up from its program in day-by-day perform. It information present applied sciences utilized in proteomics, examines the use proteomics in mobilephone signaling, provides scientific purposes of proteomics in melanoma remedy, and appears on the position of the FDA in regulating using proteomics.

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Proc. Natl. Acad. Sci. U. S. A. 96:6591–6596, 1999. 79. , III. Proc. Natl. Acad. Sci. U. S. A. 100:3107–3112, 2003. 80. , III. Anal. Chem. 76:4951–4959, 2004. 81. , Mann, M. Mol. Cell Proteomics 1:376–386, 2002. 82. , Mann M. Science 308:1472–1477, 2005. 83. , Mann, M. J. Proteome Res. 2:173–181, 2003. 84. , Aebersold, R. Nat. Biotechnol. 17:994–999, 1999. 85. P. Mol. Cell Proteomics 2:1198–1204, 2003. 86. R. Mol. Cell Proteomics 3:82–92, 2004. Chapter 1 / Current and Emerging Mass Spectrometry Instrumentation 35 87.

Absent, however, is the identification of S100A4 previously identified by our study? This may indicate that S100A4 gene is not a direct target for p53 and that there is no p53-binding site in the promoter of S100A4 gene. Therefore, additional studies with ChIP-PET on other samples using different DNA damaging agents such as IR or -radiations may show how these studies are different in dissecting p53 signaling. However, ChIP-PET might prove to be an important development both in cancer genomics and in genome biology in general.

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