By Giulio Milazzo (auth.), G. Milazzo, M. Blank (eds.)

This booklet comprises the lectures of the second one path dedicated to bioelectro­ chemistry, held in the framework of the foreign institution of Biophysics. during this path one other very huge box of bioelectrochemistry, i. e. the sphere of Membrane Phenomena, used to be thought of, which itself includes numerous diverse, yet but comparable subfields. right here back, it may be simply acknowledged that it truly is most unlikely to provide an entire and unique photograph of all membrane phenomena of organic curiosity in a quick process approximately one and part week. for this reason an identical philosophy, because the one of many first direction, used to be undefined, to choose a sequence of lectures at postgraduate point, giving a synthesis of a number of membrane phenomena selected one of the most'important ones. those lectures may still convey the big number of membrane-regulated occasions taking place in dwelling our bodies, and function sound interdisciplinary foundation to begin a unique­ ized research of organic phenomena, for which the research utilizing the twin method, physico-chemical and organic, is unavoidable. for the reason that, as already pointed out, it was once very unlikely to exhaust, even approximately, is a brief path like this, the presentation and introductory therapy of the super huge number of membrane phenomena, it may be anticipated that the 3rd path will proceed the topic of membrane phenomena deepening a few ones provided during this path and introducing a few new ones. vii CONTENTS Symbols and acronyms IX beginning handle G. MILAZZO 1 constitution of organic membranes and in their versions I J . A. HAYWARD et al.

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Natl. Acad. Sci. USA, 79,4317 (1982). [43] D. J. SALSBURY, Trans. , 62,2607 (1966). [44] Z. VEKSLI, N. SALSBURY and D. CHAPMAN, Biochim. Biophys. Acta, 183,434 (1969). [45] E. OLDFIELD, D. CHAPMAN and W. , 16, 102 (1971). [46] A. SEELIG and J. SEELIG, Biochemistry, 13,4839 (1974). [47] J. SEELIG and A. SEELIG, Q. Rev. , 13, 19 (1980). [48] M. PHILLIPS, R. WILLIAMS and D. CHAPMAN, Chem. Phys. Lipids, 3, 234 (1969). L. M. Am. Chem. , 93, 314 (1971). [50] R. SKARJUNE and E. OLDFIELD, Biochemistry, 21, 3154 (1982).

CHAPMAN, Biochemistry, 23,6765 (1984). 28 HA YW ARD et al. G. SAFFMAN and M. DELBRUCK, Proc. Natl. A cad. Sci. USA, 72, 3111 (1975). J. E. , 36,257 (1981). P. ]. A. DENCHER, Biochemistry, 20, 840 (1981). [42] R. J. CHERRY, Proc. Natl. Acad. Sci. USA, 79,4317 (1982). [43] D. J. SALSBURY, Trans. , 62,2607 (1966). [44] Z. VEKSLI, N. SALSBURY and D. CHAPMAN, Biochim. Biophys. Acta, 183,434 (1969). [45] E. OLDFIELD, D. CHAPMAN and W. , 16, 102 (1971). [46] A. SEELIG and J. SEELIG, Biochemistry, 13,4839 (1974).

If not, what is the reason why they are closed? 2) Cerebrosides in brain membranes are mixed with anpther lipid. What is the effect of the other lipid on phase-transition and hydrogen bond formation? Answer: 1) Phospholipids are absent in these membranes. These lipids form monolayer membranes without any appreciable curvature. In bacteria the radius of curvature 'is very large and local curvatures may be supported by the proteins. Experiments have been done in order to show that to introduce curvature some monopolar additives are needed.

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