By Björn H. Junker, Falk Schreiber
An creation to organic networks and techniques for his or her analysisAnalysis of organic Networks is the 1st e-book of its type to supply readers with a complete advent to the structural research of organic networks on the interface of biology and laptop technology. The booklet starts with a quick evaluation of organic networks and graph theory/graph algorithms and is going directly to discover: international community homes, community centralities, community motifs, community clustering, Petri nets, sign transduction and gene rules networks, protein interplay networks, metabolic networks, phylogenetic networks, ecological networks, and correlation networks.Analysis of organic Networks is a self-contained advent to this crucial examine subject, assumes no professional wisdom in machine technology or biology, and is offered to execs and scholars alike. every one bankruptcy concludes with a precis of details and with routines for readers to check their figuring out of the cloth provided. also, an FTP website with hyperlinks to author-provided info for the publication is accessible for deeper study.This ebook is appropriate as a source for researchers in laptop technological know-how, biology, bioinformatics, complicated biochemistry, and the existence sciences, and in addition serves as a fantastic reference textual content for graduate-level classes in bioinformatics and organic examine.
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Extra info for Analysis of Biological Networks (Wiley Series in Bioinformatics)
M. Kanehisa and S. Goto. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Research, 28:27–30, 2000. 20. F. Katagiri. Attacking complex problems with the power of systems biology. Plant Physiology, 132:417–419, 2003. 21. H. Kitano. Foundations of Systems Biology. The MIT Press, Cambridge, MA, 2001. 22. V. Kunin, L. Goldovsky, N. Darzentas, and C. A. Ouzounis. The net of life: Reconstructing the microbial phylogenetic network. Genome Research, 15:954–959, 2005. 23. T. I. Lee, N. J. Rinaldi, F.
2 GLOBAL PROPERTIES OF COMPLEX NETWORKS Following the nomenclature of Chapter 2, a network is formally represented by a graph G = (V, E), consisting of a set V of NV vertices and a set E of NE edges. We distinguish between undirected graphs, whose vertices are connected by edges without any directional information, and directed graphs (digraphs), whose edges posses directional information. Additionally, in weighted graphs, each edge (directed or undirected) is associated with a scalar value, quantifying a possible interaction strength, a cost, or a flow on the respective edge.
N. Trethewey, and L. Willmitzer. Metabolite profiling for plant functional genomics. Nature Biotechnology, 18:1157–1161, 2000. 14. C. V. Forst and K. Schulten. Phylogenetic analysis of metabolic pathways. Journal of Molecular Evolution, 52:471–489, 2001. 15. K. Havens. Scale and structure in natural food webs. Science, 257:1107–1109, 1992. 16. J. Jaeger, S. Surkova, M. Blagov, H. Janssens, D. Kosman, K. N. Kozlov, Manu, E. Myasnikova, C. E. Vanario-Alonso, M. Samsonova, D. H. Sharp, and J. Reinitz.